Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p201 | Cell biology: osteoclasts and bone resorption | ECTS2016

Galectin-1 is involved in osteoclast biology

Muller Josephine , Binsfeld Marilene , Dubois Sophie , Carmeliet Geert , Beguin Yves , Heusschen Roy , Caers Jo

Osteolytic bone disease (OBD) is a frequent complication of multiple cancers, such as multiple myeloma. OBD is due to the disruption of balanced bone remodelling, with higher bone resorption due to increased osteoclast activation and osteoblast inhibition. Lectin–glycoprotein interactions have been implicated in osteoclast formation. In the current study, we set out to identify lectins that are involved in osteoclastogenesis and to study their role in this process. We ant...